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Sulaiman, M.Sc., M.Phil, Ph.D. Microbiological Sciences Branch Southeast Regional Laboratory (SRL) Office of regulatory Affairs (ORA) Atlanta, Georgia Background:. Ph.D. – University of Delhi, India. M.Phil.

University, India. M.Sc. Research Interests: Dr. Sulaiman joined the Microbiological Sciences Branch, Southeast Regional Laboratory, U. Food and Drug Administration, Atlanta, Georgia as a Research Microbiologist on October 12th of 2008, with over 16 years of research experience and expertise in the field of molecular genetics and its application in method development to detect and differentiate various human-pathogenic emerging infectious agents.

Before coming to FDA, Dr. Sulaiman worked at the Centers for Disease Control (CDC) for eleven and half years from 1997 to 2008. Sulaiman obtained his PhD degree in 1992 to study Conservation Biology, Population Genetics and Ecology of Endangered Species from University of Delhi. Research Interests: Prior to joining FDA I conducted research in Cell Culture, Virology, Microbial Genetics and Select Agents. Research interests with FDA include rapid methods development with Select Agents in foods, virus in foods, high throughput molecular assays and methods as well as investigating nano potential for field capable real time food analysis. Proposed Regulatory Research Project for the FDA Commissioner's Fellow: The goal of the fellowship research project is to develop a portable biosensor platform for environmental and later, food analysis.

Novel biosensor concepts are needed to reduce the time to process, weight of current prototype detection platforms and to reduce the quantities of chemicals required to run them. Small foot print biosensors with multiplexing capabilities that are robust and very sensitive will meet these requirements. Small hand-held lateral flow devices are light but have sensitivity levels ranging from 105 to 107cfu/g.

Sensor platforms made from functionally derived electro-spun or melt-spun fibers can be prepared and conformally coated with conductive polymers by oxidative chemical vapor deposition (oCVD) to create electrochemical biosensor devices. The geometry of the melt-spun membrane is such that it creates an extremely high surface area for increased antibody attachment.

Our goal is to utilize masking, lithographic or nano-stencil methods to construct grids of small independent “mini-sensors” that individually can detect 1-100 positive receptor/target interactions. Combining thousands or millions of these mini-sensors will allow our biosensor(s) the chance to interact with a single or very low number of pathogens in a very large sample and still report a positive result. The main objective is to develop small hand held electrochemical field capable detection devices utilizing nonwoven materials coated with conductive polymers. Studies are investigating the choice of the nonwoven membrane material and fiber diameter, the conductive polymer coating, and the process for depositing the conductive polymer onto the membrane. Ongoing studies will identify the best methods to functionalize the conductive membranes with pathogen specific antibodies, determine optimal distribution of Ab and to determine the most effective surface attachment chemistries. Lastly, an electrochemical cell will be designed and constructed in order to convert the antibody-antigen reaction into a measurable detection signal. The completion of an optimized electrochemical cell prototype will allow us to proceed to our final goal of having each “mini-sensor” directly interfaced with a computer for ongoing and instantaneous detection capability.

Applicant Requirements: Experience working with nano-materials and particularly CVD, exposure or experience with systems engineering and or advanced degree in a relevant field with a high level of motivation and commitment will be considered. Selected Recent Publications: Torosian, S.D., Regan, P., Taylor, M. Persistence of Yersinia pestis in Seeded Bottled Water Samples. Of Micro., 2009, 55:(9) 1125-1129. Torosian, S.D., Regan, P., Doran, T., Taylor, M.

A Refrigeration Temperature of 4 °C Does Not Prevent Static Growth of Yersinia Pestis in Heart Infusion Broth. 2009, 55:(9) 1119-1124. Constructing a Secure Containment System for Select Agent Analysis Using the PathatrixTM System. Laboratory Information Bulletin, Food and Drug Administration.

2007 Glucksman-Kuis, M. Alexandra, et al Polycystic Kidney Disease: The Complete structure of the PKD1 Gene and its protein. CELL 1995 Apr. 81(2): 289-298. High, A., Rodgers, F., and Torosian, S.D.

Cloning, Nucleotide Sequence and Expression of a gene(omp M) encoding a 25 kDa Major Outer Membrane Protein of Legionella pneumophila in Escherichia coli. 1993; 139:1715-1721. Research Interests: Develop quick turnaround and high throughput technologies and methodologies for analyzing FDA regulated products.

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Proposed Regulatory Research Project for the FDA Commissioner's Fellow: The Japan’s nuclear power plant accident took place in 2011 reaffirmed an urgent need for quick screening technologies and methodologies so that quick turnaround sample triage, quick turnaround laboratory sample analysis, quick turnaround consequence management and regulatory decision making in a nuclear or radiological emergency can be realized. In a nuclear or radiological event, one of the needed fast screening analytical categories is sample triage decision making and detecting surface contaminations by radioisotopes. For performing meaningful analyses of surface contaminations by radioisotopes and designing a clear, efficient sample triage mechanism, it is essential to have a systematic understanding of how an isotope interacts with a surface, especially among food surfaces and surfaces of food packaging materials, e.g. If an isotope would stay on a surface or penetrate through a surface with a certain permeating rate. To date however, there has not been any systematic study for developing such understanding nor any methodology existing for systematically guiding sample triages and directing what types of quick turnaround analyses of radionuclides need to be followed. The objective of the proposed project is to establish knowledge base and develop a systematic understanding of the interactions between selected isotopes and surfaces of interest. Based on the understanding of the isotope/surface interactions, methodologies will be developed for guiding quick turnaround triage and analyses of radioisotopes.

The project will involve both theoretical and experimental studies on paired isotope/surface systems of interest. The experimental studies can be conducted upon paired stable isotope/surface systems. The findings of the study can also potentially benefit applications such as safer packaging materials for foods, pharmaceuticals etc., medical devices, and environment cleaning.

Applicant Requirements: Ph.D. In Chemistry or Physics with experiences in computer aided theoretical modeling, laboratory experiments, and analytical instruments.

Selected Recent Publications: “Indirect endpoint detection by chemical reaction and chemiluminescence”, L., Li, J. Morgan, William J. Wei, United States Patent, Patent No.: US 6,440,263, Aug. “Optimization of CMP process by detecting of oxide/nitride interface using IR system”, L., Li, J. Wei, United States Patent, Patent No.: US 6,261,851, July 17, 2001. “Endpoint detection by chemical reaction and photoionization”, L., Li, J. Wei, United States Patent, Patent No.: US 6,228,769, B1, May 8, 2001.

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“A Comparison of the dynamics of CO oxidation by oxygen atoms and molecules on Pt and Pd surfaces”, C. 105, 810 (1996). “The study of translational excitation of CO2 produced from CO oxidation on Pd using high resolution infrared chemiluminescence spectroscopy”, C. 103, 6806 (1995).